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Anti-PP2A Antibody, B subunit, B56 delta, clone H5D12
Species Reactivity Key Applications Host Format Antibody Type
H WB Mouse Purified Monoclonal Antibody
Description:
Anti-PP2A Antibody, B subunit, B56 delta, clone H5D12
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Trade Name:
Upstate (Millipore)
Specificity:
Human PP2A, B subunit, B56 delta. This monoclonal antibody is the delta isoform for the B56 family of protein phosphatase 2A.
Immunogen:
GST fusion protein corresponding to the N-terminus of human PP2A, B subunit, B56 delta
Clone:
H5D12
Isotype:
IgG1
Background Information:
PP2A is a heterotrimeric phosphatase, ccomposed of A, B and C subunits. The structural A and catalytic C subunits form the constitutive core of the enzyme, which associates with one of a large number of regulatory B subunits. Three families of B subunits have been identified thus far. The prototypical B (or PR55) family of subunits is encoded by three genes, Balpha, Bbeta and Bgamma . The B' (or B56) family consists of at least seven splice variantsderived from five genes. RNA's for the two members of the B'' family, PR72 and PR130, arise by alternative splicing or use of alternate transcription start sites from the same gene. Primary structures as well as functions of B and B' subunits are conserved from yeast to mammals.
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Species Reactivity:
Human
Application Notes:
Immunoblotting (1:500 to 1:2000)
Optimal working dilutions must be determined by the end user
Presentation:
Purified mouse monoclonal IgG1 antibody in PBS with 0.05% NaN3.
Storage Conditions:
Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.
UniProt Number:
Q14738
Entrez Gene Number:
NM_006245
Gene Symbol:
PPP2R5D
B56D
MGC2134
MGC8949
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an delta isoform of the regulatory subunit B56 subfamily.
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UniProt Summary:
FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
TISSUE SPECIFICITY: Isoform Delta-2 is widely expressed |