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Anti-CBX8, clone 1H10.2
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REFERENCES
Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin.
Bernstein, Emily, et al. (2006) Mol. Cell. Biol., 26: 2560-9 (2006)
A phosphorylated form of Mel-18 targets the Ring1B histone H2A ubiquitin ligase to chromatin.
Elderkin, Sarah, et al. (2007) Mol. Cell, 28: 107-20 (2007)
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus.
Dietrich, Nikolaj, et al. (2007) EMBO J., 26: 1637-48 (2007)
A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification.
Mueller, Dorothee, et al. (2007) Blood, 110: 4445-54 (2007)
Species Reactivity Key Applications Host Format Antibody Type
H WB, Mplex Mouse Purified Monoclonal Antibody
Description:
Anti-CBX8 Antibody, clone 1H10.2
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Trade Name:
Upstate (Millipore)
Specificity:
CBX8
Molecular Weight:
44 kDa
Immunogen:
GST fusion protein corresponding to amino acids 88-361 of human CBX8
Background Information:
The Polycomb (PcG) group proteins play a role in regulating normal proliferation and development, and deregulation of PcG proteins contributes to the development of cancer. PcGs maintain repression of target genes and are involved in gene silencing functions, including X chromosome inactivation. The PcGs form two major protein complexes, polycomb repressive complexes 1 and 2 (PRC1 and PRC2), that function to maintain transcriptional repression. CBX 8 is an essential component of PRC1 that promotes growth and in involved in repression of tumor suppressor genes.
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Species Reactivity:
Human
Control:
HeLa cell lysate
Quality Assurance:
routinely evaluated by immunoblot on HeLa cell lysates
Purification Method:
Protein G chromatography
Storage Conditions:
Stable for 1 year at -20°C from date of receipt
UniProt Number:
Q9HC52.3
Entrez Gene Number:
NP_038954
Gene Symbol:
CBX8
PC3
HPC3
RC1
Alternate Names:
PC3; RC1; HPC3
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Multiplexing
Brand Family:
Upstate
Product Name:
Anti-CBX8, clone 1H10.2
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 μg
Format:
Purified
Host:
Mouse
Applications:
Anti-CBX8 Antibody, clone 1H10.2 is a Mouse Monoclonal Antibody for detection of CBX8 also known as PC3, RC1, HPC3 & has been validated in WB, Mplex. |