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Anti-Desmin Antibody, rabbit monoclonal, clone Y66
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REFERENCES
The antiangiogenic 16K prolactin impairs functional tumor neovascularization by inhibiting vessel maturation.
Nguyen, Ngoc-Quynh-Nhu, et al. (2011) PLoS ONE, 6: e27318 (2011)
High level desmin expression depends on a muscle-specific enhancer.
Li, Z L and Paulin, D (1991) J. Biol. Chem., 266: 6562-70 (1991)
Human desmin-coding gene: complete nucleotide sequence, characterization and regulation of expression during myogenesis and development
Li, Z L, et al (1989) Gene, 78:243-54 (1989)
Intermediate filament structure and assembly
Stewart, M (1993) Curr Opin Cell Biol, 5:3-11 (1993)
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Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB, IH(P) Rabbit Purified Monoclonal Antibody
Description:
Anti-Desmin Antibody, rabbit monoclonal, clone Y66
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes Human, Mouse, Rat Desmin.
Immunogen:
A synthetic peptide corresponding to C-terminus of human Desmin. Predicted to cross-react with rat, bovine and pig, based on sequence homology.
Clone:
Y66
Background Information:
Desmin are class-III intermediate filaments found in muscle cells, and are expressed during the formation of muscle cells or fibers. Cytoskeletal intermediate filaments (IFs) are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice (1,2). In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. Desmin mutations have been linked to familial cardiac and skeletal myopathy (3,4).
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Species Reactivity:
Human
Mouse
Rat
Species Reactivity Note:
Positive control: Mouse heart tissue.
Application Notes:
WB: 1:500
IHC: 1:500 (Paraffin-embedded human heart muscle)
Purification Method:
Protein A purfied
Presentation:
Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage Conditions:
Store at -20 °C. Stable for 12 months from date of receipt.
UniProt Number:
P17661
Entrez Gene Number:
NM_001927.3
Gene Symbol:
DES
CSM2
FLJ41013
FLJ39719
CSM1
FLJ41793
FLJ12025
Desmin.
CMD1I
desmin
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunohistochemistry (Paraffin)
Entrez Gene Summary:
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.
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UniProt Summary:
FUNCTION: SwissProt: P17661 # Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the |