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Anti-IL-17 Antibody, rabbit monoclonal
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REFERENCES
Interleukin-17.
Fossiez, F, et al. (1998) Int. Rev. Immunol., 16: 541-51 (1998)
Human IL-17: a novel cytokine derived from T cells
Yao, Z, et al (1995) J Immunol, 155:5483-6 (1995)
Species Reactivity Key Applications Host Format Antibody Type
H, M WB Rabbit Purified Monoclonal Antibody
Description:
Anti-IL-17 Antibody, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes recombinant human IL-17.
Immunogen:
KLH-conjugated recombinant human IL-17.
Isotype:
IgG
Species Reactivity:
Human
Mouse
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
100 μL of rabbit monoclonal IgG in 60% storage buffer (50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
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UniProt Number:
Q16552
Entrez Gene Number:
NM_002190.2
Gene Symbol:
IL17A
IL-17A
CTLA-8
IL17
IL-17
CTLA8
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
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UniProt Summary:
FUNCTION: SwissProt: Q16552 # Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in fibroblasts.
SIZE: 155 amino acids; 17504 Da
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Restricted to activated memory T-cells.
PTM: Found both in glycosylated and nonglycosylated forms.
SIMILARITY: SwissProt: Q16552 ## Belongs to the IL-17 family.
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Brand Family:
Upstate
Product Name:
Anti-IL-17 Antibody, rabbit monoclonal
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 µL
Format:
Purified
Host:
Rabbit
Applications:
Anti-IL-17 Antibody, Rabbit detects level of IL-17 & has been published & validated for use in WB. |