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Anti-IL-15 Antibody, rabbit monoclonal
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REFERENCES
Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.
Giri, J G, et al. (1994) EMBO J., 13: 2822-30 (1994)
Differential intracellular trafficking, secretion and endosomal localization of two IL-15 isoforms
Gaggero, A, et al (1999) Eur J Immunol, 29:1265-74 (1999)
Species Reactivity Key Applications Host Format Antibody Type
H WB Rabbit Purified Monoclonal Antibody
Description:
Anti-IL-15 Antibody, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes recombinant human IL-15.
Molecular Weight:
15kDa
Immunogen:
KLH-conjugated recombinant human IL-15.
Isotype:
IgG
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
100 μL of rabbit monoclonal IgG in 60% storage buffer (50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
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UniProt Number:
P40933
Entrez Gene Number:
NM_000585.2
NM_172174.1
Gene Symbol:
IL15
MGC9721
IL-15
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
The protein encoded by this gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Two alternatively spliced transcript variants of this gene encoding the same protein have been reported.
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UniProt Summary:
FUNCTION: SwissProt: P40933 # Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.
SIZE: 162 amino acids; 18086 Da
SUBCELLULAR LOCATION: Isoform IL15-S48AA: Secreted. & Isoform IL15-S21AA: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.
TISSUE SPECIFICITY: Most abundant in placenta and skeletal muscle. It is also detected in th |