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Anti-c-Reactive Protein (CT) Antibody, rabbit monoclonal
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REFERENCES
Interaction of C-reactive protein with lymphocytes and monocytes: complement-dependent adherence and phagocytosis
Mortensen, R F, et al (1976) J Immunol, 117:774-81 (1976)
Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFkappa B-C/EBP-beta complex formation
Kleemann, Robert, et al (2003) Blood, 101:545-51 (2003)
Species Reactivity Key Applications Host Format Antibody Type
H WB, IH(P) Rabbit Purified Monoclonal Antibody
Description:
Anti-c-Reactive Protein (CT) Antibody, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes a region composed of residues encompassing the C-terminus of human c-Reactive Protein.
Molecular Weight:
23 kDa
Immunogen:
KLH-conjugated synthetic peptide composed of residues encompassing the C-terminus of human c-Reactive Protein.
Isotype:
IgG
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
100 μL of rabbit monoclonal IgG in 60% storage buffer (50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
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UniProt Number:
P02741
Entrez Gene Number:
NM_000567.2
Gene Symbol:
CRP
MGC149895
MGC88244
PTX1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunohistochemistry (Paraffin)
UniProt Summary:
FUNCTION: SwissProt: P02741 # Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
COFACTOR: Binds 2 calcium ions per subunit.
SIZE: 224 amino acids; 25039 Da
SUBUNIT: Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Found in plasma.
SIMILARITY: SwissProt: P02741 ## Belongs to the pentaxin family. & Contains 1 pentaxin domain.
MISCELLANEOUS: This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.
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Brand Family:
Upstate
Product Name:
Anti-c-Reactive Protein (CT) Antibody, rabbit monoclonal
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 µL
Format:
Purified
Host:
Rabbit
Applications:
Detect c-Reactive Protein (C-term) using this Anti-c-Reactive Protein (C-term) Antibody, Rabbit |