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Anti-CD3 ε Antibody, rabbit monoclonal
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REFERENCES
Signal transduction by the T cell antigen receptor.
Weiss, A, et al. (1991) Semin. Immunol., 3: 313-24 (1991)
Multiple signal transduction pathways activated through the T cell receptor for antigen
Siegel, J N, et al (1991) Semin Immunol, 3:325-34 (1991)
Species Reactivity Key Applications Host Format Antibody Type
H IF, WB Rabbit Purified Monoclonal Antibody
Description:
Anti-CD3 ε Antibody, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes a region composed of residues encompassing the cytoplasmic domain of human CD3. This antibody does not recognize the other subunits of CD3.
Molecular Weight:
23kDa
Immunogen:
KLH-conjugated synthetic peptide composed of residues encompassing the cytoplasmic domain of human CD3.
Isotype:
IgG
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
100 μL of rabbit monoclonal IgG in 60% storage buffer (50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
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UniProt Number:
P07766
Entrez Gene Number:
NM_000733.2
Gene Symbol:
CD3E
T3E
TCRE
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunofluorescence
Western Blotting
Entrez Gene Summary:
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women.
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UniProt Summary:
FUNCTION: SwissProt: P07766 # The CD3 complex mediates signal transduction.
SIZE: 207 amino acids; 23147 Da
SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P07766 ## Contains 1 Ig-like (immunoglobulin-like) domain. & Contains 1 ITAM domain.
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Brand Family:
Upstate
Product Name:
Anti-CD3 ε Antibody, rabbit monoclonal
Antibody Type:
Monoclonal An |