|
Anti-Caspase-7 Antibody, rabbit monoclonal
Close
REFERENCES
Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.
Fernandes-Alnemri, T, et al. (1995) Cancer Res., 55: 2737-42 (1995)
ICE-LAP3, a novel mammalian homologue of the Caenorhabditis elegans cell death protein Ced-3 is activated during Fas- and tumor necrosis factor-induced apoptosis
Duan, H, et al (1996) J Biol Chem, 271:1621-5 (1996)
Species Reactivity Key Applications Host Format Antibody Type
H IF, IP, WB, IH(P) Rabbit Purified Monoclonal Antibody
Description:
Anti-Caspase-7 Antibody, rabbit monoclonal
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes a region composed of residues at the N-terminus of human Caspase-7.
Molecular Weight:
34 kDa
Immunogen:
KLH-conjugated synthetic peptide composed of residues at the N-terminus of human Caspase-7.
Isotype:
IgG
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
Storage Conditions:
2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
View All »
UniProt Number:
P55210
Entrez Gene Number:
NM_001227.3
NM_033338.4
NM_033339.3
NM_033340.2
Gene Symbol:
CASP7
CASP-7
ICE-LAP3
CMH-1
MCH3
View All »
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Immunofluorescence
Immunoprecipitation
Western Blotting
Immunohistochemistry (Paraffin)
Entrez Gene Summary:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms.
View All »
UniProt Summary:
FUNCTION: SwissProt: P55210 # Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly- 217' bond. Overexpression promotes programmed cell death.
SIZE: 303 amino acids; 34277 Da
SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Highly e |