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Anti-Bak Antibody, rabbit monoclonal
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REFERENCES
Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways.
L Zhang,H Lopez,N M George,X Liu,X Pang,X Luo (2011) Cell death and differentiation.18
Identification of a specific telomere terminal transferase activity in Tetrahymena extracts
Greider, C W and Blackburn, E H (1985) Cell, 43:405-13 (1985)
The RNA component of human telomerase
Feng, J, et al (1995) Science, 269:1236-41 (1995)
Species Reactivity Key Applications Host Format Antibody Type
Human Only FC, IF, WB, IH(P) Rabbit Purified Monoclonal Antibody
Description:
Anti-Bak Antibody, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes a region near the N-terminus domain of human Bak.
Molecular Weight:
~23 kDa
Immunogen:
KLH-conjugated synthetic peptide corresponding to the N-terminal region of human Bak.
Isotype:
IgG
Species Reactivity:
Human Only
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
In 60% storage buffer (50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 0.01% sodium azide and 0.05% BSA) and 40% glycerol.
Storage Conditions:
2 year at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
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UniProt Number:
Q16611
Entrez Gene Number:
NM_001188.3
Gene Symbol:
BAK1
CDN1
BAK
BAK-LIKE
MGC3887
BCL2L7
OTTHUMP00000039620
MGC117255
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Flow Cytometry
Immunofluorescence
Western Blotting
Immunohistochemistry (Paraffin)
Entrez Gene Summary:
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
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UniProt Summary:
FUNCTION: SwissProt: Q16611 # In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the a repressor Bcl-2 or its adenovirus homolog E1B 19k protein.
SIZE: 211 amino acids; 23409 Da
SUBUNIT: Forms heterodimers with Bcl-2, E1B 19k protein, and Bcl- X(L).
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
TISSUE SPECIFICITY: Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
DOMAIN:SwissProt: Q16611 Intact BH3 mo |