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Anti-phospho-p90 RSK1 (Ser380) Antibody, rabbit monoclonal
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REFERENCES
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors.
Ballif, Bryan A, et al. (2005) Proc. Natl. Acad. Sci. U.S.A., 102: 667-72 (2005)
14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity
Cavet, Megan E, et al (2003) J Biol Chem, 278:18376-83 (2003)
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
Saitoh, Masao, et al (2002) J Biol Chem, 277:20104-12 (2002)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R IF, IP, WB Rabbit Purified Monoclonal Antibody
Description:
Anti-phospho-p90 RSK1 (Ser380) Antibody, rabbit monoclonal
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes Rsk-1 when phosphorylated on Ser380.
Molecular Weight:
90 kDa
Immunogen:
KLH-conjugated synthetic peptide corresponding to serine 380 and surrounding amino acids of human p90 RSK-1.
Modifications:
Phosphorylation
Isotype:
IgG
Species Reactivity:
Human
Mouse
Rat
Application Notes:
Suggested Dilutions:
Immunoblot Analysis: 1:10,000
Immunoprecipitation: 1:250 - 1:500
Immunfluorescence Staining: 1:50
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
100 μL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 90 mM NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage.
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UniProt Number:
Q15418
Entrez Gene Number:
NM_001006665.1
NM_002953.3
Gene Symbol:
RPS6KA1
HU-1
RSK-1
MAPKAPK1A
RSK
pp90RSK1
p90S6K
RSK1
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Alternate Names:
RPS6KA1, MAPKAPK1A, RSK, RSK1, S6K-alpha 1, ribosomal protein S6 kinase, 90kDa, polypeptide 1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunofluorescence
Immunoprecipitation
Western Blotting
Entrez Gene Summary:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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UniProt Summary:
FUNCTION: SwissProt: Q15418 # Serine/threonine kinase that may play a role in mediating the growth-factor and stress induce |