|
Anti-PKCβII Antibody, rabbit monoclonal
Close
REFERENCES
Sodium butyrate-mediated differentiation of colorectal cancer cells: regulation of PKCbetaII by PI 3-kinase.
Turecková, Jolana, et al. (2005) Int. J. Mol. Med., 15: 329-35 (2005)
Isoenzyme-specific translocation of protein kinase C (PKC)betaII and not PKCbetaI to a juxtanuclear subset of recycling endosomes: involvement of phospholipase D
Becker, Kevin P and Hannun, Yusuf A (2004) J Biol Chem, 279:28251-6 (2004)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R FC, IF, IP, WB, IH(P) Rabbit Purified Monoclonal Antibody
Description:
Anti-PKCβII Antibody, rabbit monoclonal
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes the C-terminus of PKCβII. It does not cross-react with the closely related PKCβI isoform.
Molecular Weight:
77 kDa
Immunogen:
KLH-conjugated synthetic peptide corresponding to a region in the C-terminus of human PKCβII.
Isotype:
IgG
Species Reactivity:
Human
Mouse
Rat
Quality Assurance:
Routinely evaluated by immunoblot.
Presentation:
100 µL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide, 0.03% BSA and 40% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment
UniProt Number:
P05771
Entrez Gene Number:
NM_002738.5
NM_212535.1
Gene Symbol:
PRKCB1
PRKCB
PRKCB2
PKCB
MGC41878
PKC-B
PKC-beta
View All »
Alternate Names:
Protein Kinase C
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Flow Cytometry
Immunofluorescence
Immunoprecipitation
Western Blotting
Immunohistochemistry (Paraffin)
View All »
Entrez Gene Summary:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
View All »
UniProt Summary:
FUNCTION: SwissProt: P05771 # This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May be considered as a novel component of the NF-kappa-B |