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Anti-19S regulator ATPase subunit S7/Rpt1 Antibody, clone MSS1-104
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REFERENCES
Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes.
Hendil, K B, et al. (1998) Biochem. J., 332 ( Pt 3): 749-54 (1998)
Subunit arrangement in the human 20S proteasome
Kopp, F, et al (1997) Proc Natl Acad Sci USA, 94:2939-44 (1997)
The 26S proteasome: subunits and functions
Tanaka, K and Tsurumi, C (1997) Mol Biol Rep, 24:3-11 (1997)
Species Reactivity Key Applications Host Format Antibody Type
H, M WB Mouse Purified Monoclonal Antibody
Description:
Anti-19S regulator ATPase subunit S7/Rpt1 Antibody, clone MSS1-104
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes 19S regulator ATPase subunit S7/Rpt1.
Molecular Weight:
48 kDa
Immunogen:
Full length human recombinant Rpt1 protein.
Clone:
MSS1-104
Isotype:
IgG1
Species Reactivity:
Human
Mouse
Presentation:
100 µL concentration 1.6mg/mL of purified immunoglobulin in Tris buffer containing 0.01 M sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
Storage Conditions:
Stable for 1 year at -20°C from date of shipment for up to 12 months.
UniProt Number:
P35998
Entrez Gene Number:
NM_002803.2
Gene Symbol:
PSMC2
MSS1
MGC3004
Nbla10058
S7
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Alternate Names:
26S proteasome ATPase subunit 2; S7
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex.
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UniProt Summary:
FUNCTION: SwissProt: P35998 # The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. In case of HIV-1 infection, positive modulator of Tat-mediated transactivation.
SIZE: 433 amino acids; 48634 Da
SUBUNIT: Interacts with KNTC2 and SQSTM1. Interacts with PAAF1 |