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Anti-19S regulator ATPase subunit S6b/Rpt3 Antibody, clone TBP7-27
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REFERENCES
Regulatory subunit interactions of the 26S proteasome, a complex problem.
Ferrell, K, et al. (2000) Trends Biochem. Sci., 25: 83-8 (2000)
The proteasome.
Bochtler, M, et al. (1999) Annual review of biophysics and biomolecular structure, 28: 295-317 (1999)
The 26S proteasome: subunits and functions
Tanaka, K and Tsurumi, C (1997) Mol Biol Rep, 24:3-11 (1997)
Species Reactivity Key Applications Host Format Antibody Type
H, Rb WB Mouse Purified Monoclonal Antibody
Description:
Anti-19S regulator ATPase subunit S6b/Rpt3 Antibody, clone TBP7-27
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes 19S regulator ATPase subunit S6b/Rpt3.
Molecular Weight:
47 kDa
Immunogen:
Full length human recombinant Rpt3 protein.
Clone:
TBP7-27
Isotype:
IgG1
Species Reactivity:
Human
Rabbit
Presentation:
100 µL of purified from culture supernatant in PBS containing 0.01M sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
Storage Conditions:
Stable for 1 year at -20°C from date of shipment for up to 12 months.
UniProt Number:
P43686
Entrez Gene Number:
NM_006503.2
NM_153001.1
Gene Symbol:
PSMC4
MGC23214
MGC13687
TBP-7
MGC8570
MIP224
TBP7
S6
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Alternate Names:
26S proteasome ATPase subunit 4; TBP7
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified.
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UniProt Summary:
FUNCTION: SwissProt: P43686 # The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
SIZE: 418 amino acids; 47366 Da
SUBUNIT: Interacts with NR1I3. Interacts with PAAF1.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
PTM: The N-terminus is blocked.
SIMILARITY: SwissProt: P43686 ## Belongs to the AAA ATPase family.
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