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Anti-20S proteasome subunit β3 Antibody, clone MCP102
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REFERENCES
Subunit arrangement in the human 20S proteasome
Kopp, F, et al (1997) Proc Natl Acad Sci USA, 94:2939-44 (1997)
The 26S proteasome: subunits and functions
Tanaka, K and Tsurumi, C (1997) Mol Biol Rep, 24:3-11 (1997)
Human proteasomes analysed with monoclonal antibodies
Hendil, K B, et al (1995) Biochem J, 305 ( Pt 1):245-52 (1995)
Species Reactivity Key Applications Host Format Antibody Type
H, M, R, Rb WB, IHC Mouse Purified Monoclonal Antibody
Description:
Anti-20S proteasome subunit β3 Antibody, clone MCP102
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes proteasome subunit beta type 3
Molecular Weight:
23 kDa
Immunogen:
Dinitrophenylated proteasomes
Clone:
MCP102
Isotype:
IgG1
Species Reactivity:
Human
Mouse
Rat
Rabbit
Purification Method:
Ascites
Presentation:
100 µL of purified from ascites in PBS containing 0.01M sodium azide. Dilute to working strength with phosphate buffered saline pH 7.2-7.4.
Storage Conditions:
Stable for 1 year at -20°C from date of shipment for up to 12 months.
UniProt Number:
P49720
Entrez Gene Number:
NM_002795.2
Gene Symbol:
PSMB3
HC10-II
MGC4147
Alternate Names:
proteasome subunit beta type 3
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunohistochemistry
Entrez Gene Summary:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Pseudogenes have been identified on chromosomes 2 and 12.
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UniProt Summary:
FUNCTION: SwissProt: P49720 # The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.
SIZE: 205 amino acids; 22949 Da
SUBUNIT: The proteasome is composed of at least 15 non identical subunits which form a highly ordered ring-shaped structure.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
SIMILARITY: SwissProt: P49720 ## Belongs to the peptidase T1B family.
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Brand Family:
Upstate
Product Name:
Anti-20S proteasome subunit β3 Antibody, clone MCP102
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 µL
Format:
Purified
Host:
Mouse
Applications:
Anti-20S proteasome subunit β3 Antibody, clon |