SH3 binding sequence of guanine nucleotide exchange factor hSOS which is a ligand for the adaptor protein Grb2 SH3 domain. Blocks SOS/Grb2 interaction and thereby prevents Ras activation via receptor protein tyrosine kinases. Km=5.6 µM for N-terminal SH3 of Grb2. Product Specification Alternative Name:SOS-1 (human) N10 SH3 binding domain, Ras inhibitory peptide Sequence:Val-Pro-Pro-Pro-Val-Pro-Pro-Arg-Arg-Arg MW:1169.7 Purity:>98% Appearance:Lyophilized solid. Solubility:Soluble in Water. Long Term Storage:-20°C
