|
Y-27632 (hydrochloride)
Cayman Chemical Item Number 10005583
Description
The ROCK family of Rho-associated serine-threonine protein kinases is known to play an important role in Rho-mediated cell adhesion and smooth muscle contraction. Y-27632 is a potent, ATP-competitive inhibitor of Rho-associated protein kinases including p160ROCK (Ki = 140 nM) and ROCK-II (IC50 = 800 nM). It also inhibits PRK2 with an IC50 value of 600 nM.1↗,2↗ One-hour treatment with 10 µM Y-27632 blocks apoptosis of dissociated cultured human embryonic stem cells, increasing cloning efficiency by 25% and sustaining survival up to 30 passages.3↗
Formal Name 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-trans-cyclohexanecarboxamide, dihydrochloride
CAS Number 129830-38-2
Molecular Formula C14H21N3O · 2HCl
Formula Weight 320.3
Formulation A crystalline solid
Purity >98%
λmax 204, 270 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES O=C(C1CCC([C@H](N)C)CC1)NC2=CC=NC=C2.Cl.Cl
InCHI Code 1S/C14H21N3O.2ClH/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13;;/h6-12H,2-5,15H2,1H3,(H,16,17,18);2*1H/t10-,11?,12-;;/m1../s1
InCHI Key IDDDVXIUIXWAGJ-JXIQBYSYSA-N |