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Active Human Caspases Group II
Set of recombinant proteases involved in apoptosis
Product Overview
Alternate Names / Synonyms: Caspases Group II, Active Human
Gene Symbol: CASP2 CASP3 CASP7
Accession #: CASP2- P42575 CASP3- P42574 CASP7- P55210
Gene ID: CASP2- 835 CASP3- 836 CASP7- 840
Source: E. coli
Appearance: Lyophilized
Physical Form Description: Lyophilized powder
Molecular Weight: N/A
Purity by SDS-PAGE: N/A
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A
Reconstitution Instructions: Reconstitute to 1 unit per µl in PBS.
Storage Temp.: -70°C
Shipping: Gel Pack
Background Information: Caspase family consists of more than 10 members. Based on their extended substrate specificities, these enzymes were divided into three major groups: Group I (contains caspase-1,-4,-5), Group II (contains caspase-2,-3,-7), and Group III (contains caspase-6,-8,-9,-10). Evidences have suggested that Group I caspases are involved primarily in the production of inflammatory cytokines, while group II and III enzymes function in apoptosis as effectors and upstream activators, respectively. The group caspases were expressed in E. coli and routinely tested for their ability to enzymatically cleave the substrate VDVAD-pNA (for caspase-2) and DEVD-pNA (for caspase-3 & -7).
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans. |