Active Human Caspases Group I

Active Human Caspases Group I
Set of recombinant proteases involved in apoptosis
Product Overview
Alternate Names / Synonyms: Active Human Caspases Group I, Active Human
Gene Symbol: CASP1 CASP4 CASP5
Accession #: CASP1- NP_150634.1 CASP4- P49662 CASP5- P51878
Gene ID: CASP1- 834 CASP4- 837 CASP5 -838
Source: E. coli
Appearance: Lyophilized
Physical Form Description: Lyophilized powder
Molecular Weight: N/A
Purity by SDS-PAGE: N/A
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A
Reconstitution Instructions: Reconstitute to 1 unit/µl in PBS containing 15% glycerol.
Storage Temp.: -70°C
Shipping: Gel Pack
Background Information: The caspase family consists of more than 10 members. Based on their extended substrate specificities, these enzymes were divided into three major groups: Group I (contains caspase-1,-4,-5), Group II (contains caspase-2,-3,-7), and Group III (contains caspase-6,-8,-9,-10). Evidences have suggested that Group I caspases are involved primarily in the production of inflammatory cytokines, while group II and III enzymes function in apoptosis as effectors and upstream activators, respectively. The group I caspases were expressed in E. coli and routinely tested for their ability to enzymatically cleave the substrate YVAD-pNA (for caspase-1) and WEHD-pNA (for caspase-4 & -5).
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.