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产品编号 A4888
CAS号 1397-89-3
两性霉素 B 来源于链霉菌
Amphotericin B from Streptomyces sp.
别名: Fungizone
经验分子式（希尔表示法） C47H73NO17
分子量 924.08
Biochem/physiol Actions
Amphotericin B is a polyene antifungal antibiotic from Streptomyces. It has an affinity for sterols, primarily ergosterols, of fungal cell membranes. It forms channels in the membranes, causing small molecules to leak out which contributes to cell death.
Antimicrobial spectrum: fungi and yeast.
Polyene antifungal antibiotic from Streptomyces. Affinity for sterols, primarily ergosterols, of fungal cell membranes. Forms channels in the membranes, causing small molecules to leak out.
Antimicrobial spectrum: fungi and yeast.
Application
Amphotericin B is used to study the affects of the influx of calcium on antifungal activity, 1 and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers 2,3. It is also commonly used in tissue culture as an antifungal supplement.
assay ~80% (HPLC)
form powder
solubility DMF: soluble2-4 mg/mL
DMSO: soluble30-40 mg/mL
H2O: insoluble
storage temp. 2-8°C
Appearance (Form) Powder
Appearance (Colour) Yellow to Orange
Solubility (Solvent) DMF/1M HCL 3/1
Solubility (Conc) 49.00 - 51.00 mg/ml
Solubility (Heating) Yes or No
Solubility (Turbidity) Clear to Slightly Hazy
Solubility (Color) Brown to Orange
Water (by Karl Fischer) < 6.00 % _
Elemental Anal. (%C anhydrous) 58.20 - 65.00 %
Elemental Anal. (%N anhydrous) 1.20 - 1.80 %
Purity (HPLC) > 80.00 % _
Potency (Dry Basis) > 750.00 µG/mg _
Recommended Retest Period -------------------------
5 Years
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