CXCR7 Agonist, VUF11207

CXCR7 Agonist, VUF11207
RDC-1 Agonist, GPR159 Agonist, (E)-N-(3-(2-fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide, RDC1 agonist, CMKOR1 Agonist, CXCR-7 Agonist, CXC-R7 Agonist
A styrene-amide derivative that acts as a high affinity and high potency ligand of CXCR7 chemokine receptor (pKi = 8.1) and induces the recruitment of β-arrestin2 and subsequent interenalization of CXCR7. Exposure of HEK293 T cells transiently transfected with cDNA encoding both CXCR7-RLuc and β-arrestin 2-YFP to VUF11207 is shown to induce a dose-dependent increase in bioluminescence resonance energy transfer (BRET) signal (EC50 = 1.6 nM) indicating its agonist role in β-arrestin2 is recruited to the active receptor.
产品信息
Form  Light yellow oil
Primary Target  CXCR7
Molar mass  470.6
Protect from Light  是的
Packaged under inert gas  是的
Cell permeable  是的
Reversible  是的
Purity  ≥99% by HPLC
Solubility  DMSO
商店和运输信息
Storage  -20°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling