InSolution? CFTR Inhibitor II, GlyH-101

InSolution™ CFTR Inhibitor II, GlyH-101
N-(2-Naphthalenyl)-((3,5-dibromo-2,4-dihydroxyphenyl)methylene)glycine hydrazide
A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 µM; Ki = 4.3 µM in CFTR-expressing FRT cells for apical membrane Cl- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl- currents, and is effective in nasal and intestinal epithelia in vivo.
产品信息
Form  Liquid
Formulation  A 25 mM (5 mg/406 µL) solution of CFTR Inhibitor II, GlyH-101 (Cat. No. 219671) in DMSO.
Primary Target  CFTR
Primary Target Ki  4.3 µ
Molar mass  493.2
Protect from Light  是的
Hygrocopic  是的
Avoid freeze/thaw  是的
Packaged under inert gas  是的
Cell permeable  是的
Reversible  是的
Purity  ≥97% by HPLC
CAS number  328541-79-3
商店和运输信息
Storage  ≤ -70°C
Ship  Dry Ice Only
Irritant
安全标示
S Phrase  S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
R Phrase  R: 36/38
Irritating to eyes and skin.