Caspase-6 Inhibitor XII, pep419

Caspase-6 Inhibitor XII, pep419
An 18-mer synthetic peptide that acts as a selective, non-competitive inhibitor of caspase-6 (IC50 = 8.6 µM). Blocks the activity of processed caspase-6 as evidenced by its reduced ability to process VEID-AMC substrate. Exhibits only a trivial effect on caspase-9 and 7 and does not affect the activities of caspases 1, 2, 3, 4, 5, 8, and 10. Acts as an allosteric peptide ligand that binds outside the active site of the enzyme and impairs its activity. Pep419 is shown to bind as a dimer to an allosteric site of caspase-6 zymogen resulting in its tetramerizaton and stabilization. Its binding site is shown to be distinct from the substrate binding site of the enzyme. Electroporation has been shown to enable the entry of 5-carboxyfluorescein-labeled peptide into SKNAS bone marrow neuroblastoma cells.
产品信息
Peptide Sequence  Ac-TEKEKGRLHCVEWTILER-NH2
Form  White powder
Formulation  Supplied as a trifluoroacetate salt.
Molar mass  2268.6
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Solubility  H2O
Chemical formula  C99H162N30O29S
商店和运输信息
Storage  -20°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling