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Bax Activator, BAM7
Bax Activating Molecule 7, (E)-4-(2-(2-Ethoxyphenyl)hydrazono)-3-methyl-1-(4-phenylthiazol-2-yl)-1H-pyrazol-5(4H)-one, HBr
A cell-permeable pyrazolone compound that triggers Bax conformational changes by targeting Bax N-terminal face "BH3 trigger site" formed by the confluence of α-helices 1 &2 in a reversible manner (IC50 = 4.41 µM against 50 nM BIM BH3-derived peptide for Bax binding), leading to dose-dependent Bax oligomerization induction, Bax mitochondria translocation, and eventual Bax-dependent apoptotic cell death (33%, 90% and 94% survival rate in Bak-/-, Bak-/- Bax-/-, and Bax-/- MEF cultures, respectively; 10 µM for 24 h).
产品信息
Form Orange powder
Primary Target Bax
Molar mass 486.4
Protect from Light 是的
Packaged under inert gas 是的
Cell permeable 是的
Reversible 是的
Purity ≥99% by HPLC
Solubility DMSO
Chemical formula C21H19N5O2S • HBr
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling |