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ERK Kinase Kinase 5 Inhibitor
Apoptosis Signal-Regulating Kinase 1 Inhibitor, ASK-1 Inhibitor, MAP Kinase Kinase Kinase 5 Inhibitor, MAP3K5 Inhibitor, MAPKKK5 Inhibitor, MEKK5 Inhibitor, N-(6-(1H-Imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-tert-butylbenzamide, 2HCl, N-(6-(1H-Imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl)-4-(2-methyl-2-propanyl)benzamide, 2HCl, 4-tert-Butyl-N-(6-(1H-imidazol-1-yl)imidazo(1,2-a)pyridin-2-yl)benzamide, 2HCl
A cell-permeable imidazopyridine compound that acts as a potent, ATP-binding site-targeting ASK1/MEKK5-selective inhibitor (IC50 = 14 and 500 nM, respectively, against ASK1 and ASK2/MEKK6), while exhibiting much reduced or no activity toward a panel of 195 other kinases. Shown to inhibit STZ- (1 mM; Cat. No. 572201) induced JNK and p38 phosphorylation in INS-1 pancreatic β cells (IC50 <300 nM) and be orally available in rats in vivo.
产品信息
Form White powder
Primary Target ASK1/MEKK5
Primary Target IC50 14 and 500 nM, respectively, against ASK1 and ASK2/MEKK6
Molar mass 432.4
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Cell permeable 是的
Reversible 是的
Purity ≥99% by HPLC
Solubility DMSO or H2O
CAS number 1005775-56-3
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling |