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UPK3A, human recombinant
Immunohistochemical marker for primary and metastatic urothelial carcinomas
Product Overview
Product Name: UPK3A, human recombinant
Alternate Name/Synonyms: Uroplakin 3A, UPK3, UPIII, Uroplakin III, UP3A
Gene Symbol: UPK3A
Accession #: O75631
Gene ID: 7380
Source: E. Coli
Appearance: Liquid
Physical Form Description: Sterile filtered colorless solution of 0.25 mg/ml containing 20 mM Tris-HCl buffer (pH 8.0), 150 mM NaCl, 2 mM DTT and 20% glycerol.
Molecular Weight: 23.1 kDa
Purity by SDS-PAGE: ≥90%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A
Reconstitution Instructions: N/A
Storage Temp.: -20°C
Shipping: Gel pack
Background Information: UPK3A is a member of the uroplakin-3 family. Uroplakins (UP) which are transmembrane proteins are important components of the urothelium that pass the lipid bilayer once (UPII, UPIIIa, and UPIIIb) or four times (UPIa and UPIb; both members of the "tetraspanin" family). All hold great luminal/extracellular domains, but only UPIIIa and UPIIIb have significant cytoplasmic shares in their C-termini. UPK3A is an extremely specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Alterations in this gene are related to renal adysplasia.
Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMVNLQP QLASVTFATN NPTLTTVALE KPLCMFDSKE ALTGTHEVYL YVLVDSAISR NASVQDSTNT PLGSTFLQTE GGRTGPYKAV AFDLIPCSDL PSLDAIGDVS KASQILNAYL VRVGANGTCL WDPNFQGLCN PPLSAATEYR FKYVLVNMST GLVEDQTLWS DPIRTNQLTP YSTIDTWPGR RSGG
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans. |