IL-17B, Human Recombinant

IL-17B, Human Recombinant
A cytokine expressed by T-cells, which stimulates the release of TNF-α and IL-1β from cells of the monocyte lineage
Product Overview
Product Name: IL-17B, Human Recombinant
Alternate Name/Synonyms: IL20, NIRF
Gene Symbol: IL17B
Accession #: Q9UHF5
Gene ID: 27190
Source: E. coli
Appearance: Lyophilized powder
Physical Form Description: Sterile filtered through a 0.2 micron filter. Lyophilized from 1x PBS, pH 7.5.
Molecular Weight: 36.6 kDa
Purity by SDS-PAGE: ≥98%
Purity by HPLC: N/A
Endotoxin Level: < 0.1 ng/μg of protein (<1EU/μg).
Biological Activity: Determined by its ability to induce IL-8 production in human PBMCs using a concentration range of 10.0-100.0 ng/ml. Please note: Results may vary with PBMC donors.
Reconstitution Instructions: Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Storage Temp.: -20°C
Shipping: Gel pack
Background Information: IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17B is expressed by T-cells and has been shown to stimulate release of TNF-α and IL-1β from cells of the monocyte lineage. Recombinant human IL-17B is a 36.6 kDa nondisulfide-linked homodimer of two 161 amino acid polypeptide chains.
Amino Acid Sequence: MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.