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Procathepsin K, mouse recombinant
Predominant proteinase responsible for the resorption of the bone matrix.
Product Overview
Product Name: Procathepsin K, mouse recombinant
Alternate Name/Synonyms: Cathepsin O, Cathepsin O2, Cathepsin X, CTSK, CTSO, CTSO2
Gene Symbol: CATK
Accession #: P43235
Gene ID: 1513
Source: E. coli
Appearance: Liquid
Physical Form Description: 2.5 mg/ml solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0).
Molecular Weight: 35.5 kDa
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Dry ice
Background Information: Cathepsin K is a member of the papain cysteine proteinase family and has been identified as the predominant proteinase responsible for the resorption of the bone matrix. The enzyme cleaves proteins such as collagen type I, collagen type II and osteonectin and therefore plays a role in bone remodeling and resorption in diseases such as osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is synthesized as an inactive proenzyme (35.1 kDa) that is converted to its mature active form (23.6 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of procathepsin K to mature cathepsin K is autocatalytic.
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans. |