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GW-5074
A c-RAF1 kinase inhibitor
Product Overview
Product Name: GW-5074
Alternate Name/Synonyms: 3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-1,3-dihydroindol-2-one
Description: Cell-permeable. A potent inhibitor of cRAF1 kinase (IC₅₀ = 9 nM). Displays 100-fold selectivity for cRAF1 over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Displays neuroprotective effects in vivo via a mechanism that is independent of MEK, ERK, and Akt signaling.
Peptide Sequence: N/A
Appearance: Dark orange solid
Formulation: N/A
CAS Number: 220904-83-6
Molecular Formula: C15H8Br2INO2
Molecular Weight: 520.95
Purity: ≥98% by TLC
Solubility:DMSO (~50 mg/ml)
Storage Temp.: -20 ̊C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: C1=CC2=C(C=C1I)C(=CC3=CC(=C(C(=C3)Br)O)Br)C(=O)N2
InChi: InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
InChi Key: LMXYVLFTZRPNRV-KMKOMSMNSA-N
PubChem CID: 5924208
MDL Number: MFCD03453076
USAGE: For Research Use Only! Not For Use in Humans. |