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HPI-1
A potent Hedgehog signaling pathway inhibitor
Product Overview
Product Name: HPI-1
Alternate Name/Synonyms: 2-Methoxyethyl 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylate
Description: HPI-1 is a Hedgehog pathway inhibitor acting downstream of Smo and independently of PKA, PI3K and MAPK. It can suppress Hh pathway activation induced by loss of Su(fu) or Gli overexpression. Inhibits both endogenous and exogenous Gli1/Gli2 activity. IC₅₀’s range from 0.2 to 6 µM for various cell-based assays.
Peptide Sequence: N/A
Appearance: Yellow solid
Formulation: N/A
CAS Number: 599150-20-6
Molecular Formula: C27H29NO6 . XH2O
Molecular Weight: 463.52
Purity: ≥98% by TLC
Solubility:DMSO (~25 mg/ml) or EtOH (~25 mg/ml)
Storage Temp.: -20 ̊C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: CC1=C(C(C2=C(N1)CC(CC2=O)C3=CC=CC=C3OC)C4=CC(=CC=C4)O)C(=O)OCCOC.O
InChi: InChI=1S/C27H29NO6.H2O/c1-16-24(27(31)34-12-11-32-2)25(17-7-6-8-19(29)13-17)26-21(28-16)14-18(15-22(26)30)20- 9-4-5-10-23(20)33-3;/h4-10,13,18,25,28-29H,11-12,14-15H2,1-3H3;1H2
InChi Key: BOASXIAGFOONSK-UHFFFAOYSA-N
PubChem CID: 71311904
MDL Number: MFCD17215941
USAGE: For Research Use Only! Not For Use in Humans. |