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(±)-Blebbistatin
A selective non-muscle myosin II ATPases inhibitor
Product Overview
Product Name: (±)-Blebbistatin
Alternate Name/Synonyms: (±)-1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
Description: Cell-permeable. A selective inhibitor of non-muscle myosin II ATPases. It rapidly and reversibly inhibits Mg-ATPase activity and in vitro motility of non-muscle myosin IIA and IIB for several species (IC₅₀ = 0.5-5.0 μM), while weakly inhibiting smooth muscle myosin (IC₅₀ = 80 μM). Through these effects, blebbistatin reversibly blocks apoptosis-related bleb formation, directed cell migration and cytokinesis in vertebrate cells.
Peptide Sequence: N/A
Appearance: Yellow solid
Formulation: N/A
CAS Number: 674289-55-5
Molecular Formula: C18H16N2O2
Molecular Weight: 292.34
Purity: ≥98% by HPLC
Solubility:DMSO (~25 mg/ml)
Storage Temp.: -20 ̊C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: CC1=CC2=C(C=C1)N=C3C(C2=O)(CCN3C4=CC=CC=C4)O
InChi: InChI=1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3
InChi Key: LZAXPYOBKSJSEX-UHFFFAOYSA-N
PubChem CID: 3476986
MDL Number: MFCD04113775
USAGE: For Research Use Only! Not For Use in Humans. |