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EPZ-6438
A potent EZH2 inhibitor
Product Overview
Product Name: EPZ-6438
Alternate Name/Synonyms: N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4'-(morpholinomethyl)-[1,1'-biphenyl]-3-carboxamide; E-7438
Description: A potent and selective inhibitor of histone methyltransferase EZH2. EPZ-6438 specifically inhibits cellular H3K27 methylation leading to selective apoptotic killing of SMARCB1 mutant MRT cells. It also induces neuronal differentiation and cell cycle inhibition while suppressing expression of Hedgehog (Hh) pathway genes.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1403254-99-8
Molecular Formula: C34H44N4O4
Molecular Weight: 572.74
Purity: ≥98% by HPLC
Solubility:DMSO (>50 mg/ml)
Storage Temp.: -20 ̊C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: CCN(C1CCOCC1)C2=CC(C3=CC=C(CN4CCOCC4)C=C3)=CC(C(NCC5=C(C)C=C(C)NC5=O)=O)=C2C
InChi: InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40)
InChi Key: NSQSAUGJQHDYNO-UHFFFAOYSA-N
PubChem CID: N/A
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |