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EPZ004777
A potent DOT1L inhibitor
Product Overview
Product Name: EPZ004777
Alternate Name/Synonyms: 1-(3-((((2R,3S,4R,5R)-5-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(isopropyl)amino)propyl)-3-(4-(tert-butyl)phenyl)urea
Description: A potent and selective DOT1L inhibitor. Treatment of leukemic cells with EPZ004777 results in selective killing of those cells bearing the MLL (mixed lineage leukemia) gene translocation, with little effect on non-MLL-translocated cells.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1338466-77-5
Molecular Formula: C28H41N7O4
Molecular Weight: 539.67
Purity: ≥98% by HPLC
Solubility:DMSO
Storage Temp.: -20 ̊C
Shipping Conditions: gel pack
Handling: Protect from light and air
SMILES: CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)CC2C(C(C(O2)N3C=CC4=C3N=CN=C4N)O)O
InChi: InChI=1S/C28H41N7O4/c1-17(2)34(13-6-12-30-27(38)33-19-9-7-18(8-10-19)28(3,4)5)15-21-22(36)23(37)26(39-21)35-14-11-20-24(29)31-16-32-25(20)35/h7-11,14,16-17,21-23,26,36-37H,6,12-13,15H2,1-5H3,(H2,29,31,32)(H2,30,33,38)/t21?,22-,23-,26?/m1/s1
InChi Key: WXRGFPHDRFQODR-QQNJPBSNSA-N
PubChem CID: 70702060
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |