|
AGI-5198
A potent, selective inhibitor of mutant IDH1 (isocitrate dehydrogenase 1)
Product Overview
Product Name: AGI-5198
Alternate Name/Synonyms: N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide; IDH-C35
Description: A potent, selective inhibitor of mutant IDH1 (isocitrate dehydrogenase 1). AGI-5198 inhibits IDH1 R132H and R132C mutants in vitro with IC₅₀ values of 0.07 and 0.16 µM, respectively, but not wild-type IDH1, wild-type IDH2, or IDH2 mutants (IC₅₀ s > 100 μM). Under conditions of near complete 2-HG (2-hydroxyglutarate) inhibition, AGI-5198 can induce demethylation of histone H3K9me3 and expression
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1355326-35-0
Molecular Formula: C27H31FN4O2
Molecular Weight: 462.56
Purity: ≥98% by HPLC
Solubility:DMSO (~25 mg/ml) or Ethanol (~ 15 mg/ml)
Storage Temp.: -20 ̊C
Shipping Conditions: gel pack
Handling: Protect from light and moisture
SMILES: CC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C
InChi: InChI=1S/C27H31FN4O2/c1-19-9-6-7-14-24(19)26(27(34)30-22-11-4-3-5-12-22)32(23-13-8-10-21(28)17-23)25(33)18-31-16-15-29-20(31)2/h6-10,13-17,22,26H,3-5,11-12,18H2,1-2H3,(H,30,34)
InChi Key: FNYGWXSATBUBER-UHFFFAOYSA-N
PubChem CID: 56645356
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |