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Borrelidin
An angiogenesis inhibitor
Product Overview
Product Name: Borrelidin
Alternate Name/Synonyms: Treponemycin; U 78548; C2989
Description: A macrolide antibiotic isolated from Streptomyces sp. An antiangiogenic (IC₅₀ = 0.8 nM) agent. Bacterial and eukaryal threonyl-tRNA synthetase (THrRS) inhibitor. Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Also acts as a CDK inhibitor.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 7184-60-3
Molecular Formula: C28H43NO6
Molecular Weight: 489.64
Purity: ≥98% by HPLC
Solubility:DMSO (~10 mg/ml)
Storage Temp.: -20 ̊C
Shipping Conditions: gel pack
Handling: Protect from light and moisture
SMILES: CC1CC(CC(C(C(=CC=CCC(OC(=O)CC(C(C1)C)O)C2CCCC2C(=O)O)C#N)O)C)C
InChi: InChI=1S/C28H43NO6/c1-17-12-18(2)14-20(4)27(32)21(16-29)8-5-6-11-25(22-9-7-10-23(22)28(33)34)35-26(31)15-24(30)19(3)13-17/h5-6,8,17-20,22-25,27,30,32H,7,9-15H2,1-4H3,(H,33,34)/b6-5+,21-8-/t17-,18+,19-,20-,22+,23+,24-,25-,27+/m0/s1
InChi Key: OJCKRNPLOZHAOU-UGKRXNSESA-N
PubChem CID: 6436801
MDL Number: MFCD01740784
USAGE: For Research Use Only! Not For Use in Humans. |