|
Apremilast
A potent PDE4 (phosphodiesterase 4) inhibitor
Product Overview
Product Name: Apremilast
Alternate Name/Synonyms: N-{2-[(1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide
Description: Apremilast is a potent PDE4 (phosphodiesterase 4) inhibitor (IC₅₀ = 74 nM). It reduces TNF-α production in human synovial cells and significantly suppresses experimental arthritis.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 608141-41-9
Molecular Formula: C22H24N2O7S
Molecular Weight: 460.5
Purity: ≥98% by HPLC
Solubility:DMSO (80 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CCOC1=C(C=CC(=C1)C(CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC
InChi: InChI=1S/C22H24N2O7S/c1-5-31-19-11-14(9-10-18(19)30-3)17(12-32(4,28)29)24-21(26)15-7-6-8-16(23-13(2)25)20(15)22(24)27/h6-11,17H,5,12H2,1-4H3,(H,23,25)/t17-/m1/s1
InChi Key: IMOZEMNVLZVGJZ-QGZVFWFLSA-N
PubChem CID: 11561674
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |