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SKPin C1
An ubiquitin E3 ligase inhibitor
Product Overview
Product Name: SKPin C1
Alternate Name/Synonyms: 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid
Description: Inhibits the cullin-RING ubiquitin E3 ligase SCF-Skp2. Selectively inhibits Skp2-mediated p27 degradation by reducing p27 binding. In cancer cells, the compound induces p27 accumulation and promotes cell type-specific blocks in G1 or G2/M phases.
Peptide Sequence: N/A
Appearance: Yellow solid
Formulation: N/A
CAS Number: 432001-69-9
Molecular Formula: C18H13BrN2O4S2
Molecular Weight: 465.34
Purity: ≥98% by TLC
Solubility: DMSO (15 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: BrC1=CC(/C=C2SC(N(CC3=CN=CC=C3)C2=O)=S)=C(OCC(O)=O)C=C1
InChi: 1S/C18H13BrN2O4S2/c19-13-3-4-14(25-10-16(22)23)12(6-13)7-15-17(24)21(18(26)27-15)9-11-2-1-5-20-8-11/h1-8H,9-10H2,(H,22,23)/b15-7-
InChi Key: IYCJJVVXEHZJHE-CHHVJCJISA-N
PubChem CID: N/A
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |