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Sulfo-SMCC
A water-soluble heterobifunctional protein crosslinker
Product Overview
Product Name: Sulfo-SMCC
Alternate Name/Synonyms: 4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt
Description: KEY FEATURES:
• Amine reactive Sulfo-NHS ester that crosslinks efficiently with primary amine-containing molecules
• Has a maleimide functional group that can be utilized to react specifically with cysteines or sulfhydryl (-SH) groups
• Water-soluble; can be used under physiologic conditions
• Has a spacer arm length of 8.3 Å (9 atom)
• Unlike other maleimide-activated antibodies, those made with Sulfo-SMCC crosslinkers are often more stable, due to the inductive stabilizing effects of the cyclohexyl ring moeity
APPLICATIONS:
• Routinely used to prepare hapten-carrier protein and antibody-enzyme conjugates, such as HRP conjugation.
• Wide range of uses for both small molecule reactions and large biomolecule applications.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 92921-24-9
Molecular Formula: C₁₆H₁₇N₂NaO₉S
Molecular Weight: 436.37
Purity: ≥90% by NMR
Solubility:H₂O (>10 mg/ml)
Storage Temp.: -20 ̊C
Shipping Conditions: Gel Pack
Handling: Protect from moisture
SMILES: C1CC(CCC1CN2C(=O)C=CC2=O)C(=O)ON3C(=O)CC(C3=O)S(=O)(=O)[O-].[Na+]
InChi: InChI=1S/C16H18N2O9S.Na/c19-12-5-6-13(20)17(12)8-9-1-3-10(4-2-9)16(23)27-18-14(21)7-11(15(18)22)28(24,25)26;/h5-6,9-11H,1-4,7-8H2,(H,24,25,26);/q;+1/p-1
InChi Key: VUFNRPJNRFOTGK-UHFFFAOYSA-M
PubChem CID: 4618794
MDL Number: MFCD00054978
USAGE: For Research Use Only! Not For Use in Humans. |