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Cyt387
A potent JAK1 and JAK2 inhibitor
Product Overview
Product Name: Cyt387
Alternate Name/Synonyms: (N-(cyanomethyl)-4-(2-(4-morpholinophenylamino)pyrimidin-4-l)-benzamide; CYT11387
Description: Cyt387 is an ATP-competitive inhibitor of JAK1 and JAK2 with IC₅₀ values of 11 nM and 18 nM, respectively. Inhibits JAK3 at much higher concentrations (IC₅₀ = 155 nM).
Peptide Sequence: N/A
Appearance: Yellow to light orange solid
Formulation: N/A
CAS Number: 1056634-68-4
Molecular Formula: C₂₃H₂₂N₆O₂
Molecular Weight: 414.46
Purity: ≥98% by HPLC
Solubility:DMSO (~80 mg/ml) or Ethanol (<1 mg/ml)
Storage Temp.: -20 ̊C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N
InChi: InChI=1S/C23H22N6O2/c24-10-12-25-22(30)18-3-1-17(2-4-18)21-9-11-26-23(28-21)27-19-5-7-20(8-6-19)29-13-15-31-16-14-29/h1-9,11H,12-16H2,(H,25,30)(H,26,27,28)
InChi Key: ZVHNDZWQTBEVRY-UHFFFAOYSA-N
PubChem CID: 25062766
MDL Number: MFCD16038899
USAGE: For Research Use Only! Not For Use in Humans. |