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AMI-5
A protein methyltransferase inhibitor
Product Overview
Product Name: AMI-5
Alternate Name/Synonyms: 2′,4′,5′,7′-Tetrabromofluorescein disodium salt, Acid Red 87, Bromo acid J. TS, XL, or XX, Bromofluorescein, Bronze Bromo ES, Eosin yellowish
Description: AMI-5 is a non-specific small molecule inhibitor of protein arginine methyltransferases (PRMTs) (IC₅₀ = 0.78 and 1.41 µM against Hmt1p and PRMT1, respectively) and histone lysine methyltransferases (HKMTs) (DOT1 and SET7, but not Suv39H1 and Suv39H2).
Peptide Sequence: No
Appearance: Brown to dark red solid
Formulation: N/A
CAS Number: 17372-87-1
Molecular Formula: C₂₀H₆Br₄Na₂O₅
Molecular Weight: 691.85
Purity: ≥90% (based on the anhydrous material)
Solubility:H2O (1 mg/ml)
Storage Temp.: +4 ̊C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C1=CC=C(C(=C1)C2=C3C=C(C(=O)C(=C3OC4=C(C(=C(C=C24)Br)[O-])Br)Br)Br)C(=O)[O-].[Na+].[Na+]
InChi: InChI=1S/C20H8Br4O5.2Na/c21-11-5-9-13(7-3-1-2-4-8(7)20(27)28)10-6-12(22)17(26)15(24)19(10)29-18(9)14(23)16(11)25;;/h1-6,25H,(H,27,28);;/q;2*+1/p-2
InChi Key: SEACYXSIPDVVMV-UHFFFAOYSA-L
PubChem CID: 11048
MDL Number: MCFD00005040
USAGE: For Research Use Only! Not For Use in Humans. |