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LY2886721
A potent selective β-secretase (BACE-1) inhibitor.
Product Overview
Product Name: LY2886721
Alternate Name/Synonyms: N-(3-((4aS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide
Description: Cell-permeable. A potent and selective β-secretase (BACE-1) inhibitor (IC₅₀ = 20 nM for recombinant hBACE1). Does not inhibit other aspartyl proteases such as cathepsin D, pepsin, and renin. A potential agent to treat Alzheimer’s Disease.
Peptide Sequence: No
Appearance: White solid
Formulation: N/A
CAS Number: 1262036-50-9
Molecular Formula: C₁₈H₁₆F₂N₄O₂S
Molecular Weight: 390.41
Purity: ≥98% by HPLC
Solubility:DMSO (~10 mg/ml) or Ethanol (<1 mg/ml)
Storage Temp.: -20 ̊C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C1C2CSC(=NC2(CO1)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)F)F)N
InChi: InChI=1S/C18H16F2N4O2S/c19-11-1-4-15(22-6-11)16(25)23-12-2-3-14(20)13(5-12)18-9-26-7-10(18)8-27-17(21)24-18/h1-6,10H,7-9H2,(H2,21,24)(H,23,25)/t10-,18-/m0/s1
InChi Key: NIDRNVHMMDAAIK-YPMLDQLKSA-N
PubChem CID: 49837968
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |