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GSK1904529A
A potent IGF-1 R inhibitor
Product Overview
Product Name: GSK1904529A
Alternate Name/Synonyms: N-(2,6-difluorophenyl)-5-(3-(2-(5-ethyl-2-methoxy-4-(4-(4-(methylsulfonyl)piperazin-1-yl)piperidin-1-yl)phenylamino)pyrimidin-4-yl)H-imidazo[1,2-a]pyridin-2-yl)-2-methoxybenzamide
Description: A potent, selective, reversible and ATP-competitive inhibitor of the insulin-like growth factor-1 receptor (IGF-1R) and Insulin Receptor (IR) with IC₅₀s of 27 and 25 nM, respectively.
Peptide Sequence: No
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1089283-49-7
Molecular Formula: C₄₄H₄₇F₂N₉O₅S
Molecular Weight: 851.96
Purity: ≥98% by HPLC
Solubility:DMSO (>100 mg/ml)
Storage Temp.: -20 ̊C
Shipping Conditions: gel pack
Handling: Protect from light and moisture
SMILES: CCC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)S(=O)(=O)C)OC)NC4=NC=CC(=N4)C5=C(N=C6N5C=CC=C6)C7=CC(=C(C=C7)OC)C(=O)NC8=C(C=CC=C8F)F
InChi: InChI=1S/C44H47F2N9O5S/c1-5-28-26-35(38(60-3)27-36(28)53-19-15-30(16-20-53)52-21-23-54(24-22-52)61(4,57)58)49-44-47-17-14-34(48-44)42-40(50-39-11-6-7-18-55(39)42)29-12-13-37(59-2)31(25-29)43(56)51-41-32(45)9-8-10-33(41)46/h6-14,17-18,25-27,30H,5,15-16,19-24H2,1-4H3,(H,51,56)(H,47,48,49)
InChi Key: MOSKATHMXWSZTQ-UHFFFAOYSA-N
PubChem CID: 25124816
MDL Number: MFCD17010271
USAGE: For Research Use Only! Not For Use in Humans. |