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SB 939
A pan-HDAC inhibitor
Product Overview
Product Name: SB 939
Alternate Name/Synonyms: 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-2E-propenamide; Pracinostat
Description: An orally available pan-histone deacetylase (HDAC) inhibitor binding all HDAC isozymes with similar affinity (Kis = 16-28 nM) with the exception of HDAC6 and 7 (Kis = 247 and 104 nM, respectively). SB 939 demonstrates good bioavailability in vivo and significantly inhibits tumor growth in various xenograft mouse models at doses ranging from 25-100 mg/kg.
Peptide Sequence: No
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 929016-96-6
Molecular Formula: C₂₀H₃₀N₄O₂
Molecular Weight: 358.48
Purity: ≥98%
Solubility:DMSO
Storage Temp.: -20 ̊C
Shipping Conditions: gel pack
Handling: Protect from light and moisture
SMILES: CCCCC1=NC2=C(N1CCN(CC)CC)C=CC(=C2)C=CC(=O)NO
InChi: InChI=1S/C20H30N4O2/c1-4-7-8-19-21-17-15-16(10-12-20(25)22-26)9-11-18(17)24(19)14-13-23(5-2)6-3/h9-12,15,26H,4-8,13-14H2,1-3H3,(H,22,25)/b12-10+
InChi Key: JHDKZFFAIZKUCU-ZRDIBKRKSA-N
PubChem CID: 49855250
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |