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Atorvastatin
A potent HMG-CoA reductase inhibitor
Product Overview
Product Name: Atorvastatin
Alternate Name/Synonyms: 2-(4-fluorophenyl)-βR,δR-dihydroxy-5-(1-methylethyl)-3-phenyl- 4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid
Description: A cholesterol lowering drug and a competitive inhibitor of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase (IC₅₀ = 154 nM) a rate limiting enzyme in cholesterol synthesis. Blocks the production of mevalonate, a critical compound in the production of cholesterol and isoprenoids. In addition to inhibiting cholesterol synthesis, atorvastatin reduces the production of low-density lipoprotein (LDL).
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 134523-00-5
Molecular Formula: C₃₃H₃₅FN₂O₅
Molecular Weight: 558.64
Purity: ≥98%
Solubility:DMSO (~15 mg/ml) or EtOH (~0.5 mg/ml)
Storage Temp.: -20 ̊C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC(C)C1=C(C(=C(N1CCC(CC(CC(=O)O)O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4
InChi: InChI=1S/C33H35FN2O5/c1-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40/h3-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40)/t26-,27-/m1/s1
InChi Key: XUKUURHRXDUEBC-KAYWLYCHSA-N
PubChem CID: 60823
MDL Number: MFCD00899261
USAGE: For Research Use Only! Not For Use in Humans. |