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Ramatroban
Description
A thromboxane receptor antagonist, a CRTH2 antagonist. It is indicated for the treatment of coronary artery disease. It has also been used for the treatment of asthma.
Specifications
Cas No. 116649-85-5
Product ID R0248
Product Name Ramatroban
Formula Wt. 416.47
Store Temp Ambient
References Sugimoto H, Shichijo M, Iino T, et al. (April 2003). "An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro". J. Pharmacol. Exp. Ther. 305 (1): 347–52. Royer JF, Schratl P, Carrillo JJ, et al. (September 2008). "A novel antagonist of prostaglandin D2 blocks the locomotion of eosinophils and basophils". Eur. J. Clin. Invest. 38 (9): 663–71. Fiedler VB, Seuter F, Perzborn E (December 1990). "Effects of the novel thromboxane antagonist Bay U 3405 on experimental coronary artery disease". Stroke 21 (12 Suppl): IV149–51. PMID 2260140. Endo S, Akiyama K (November 1996). "[Thromboxane A2 receptor antagonist in asthma therapy]" (in Japanese). Nippon Rinsho 54 (11): 3045–8. PMID 8950952.
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