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Auranofin
Leukocyte activation pathways inhibitor
Product Overview
Product Name: Auranofin
Alternate Name/Synonyms: 1-Thio-β-D-glucopyranosatotriethylphosphine gold-2,3,4,6-tetraacetate; SKF39162
Description: An anti-arthritic drug that inhibits various leukocyte activation pathways at multiple sites. Inhibits release of inflammatory mediators from human basophils, pulmonary mast cells and macrophages. Also inhibits human neutrophil 5-lipoxygenase. Inhibits IκB kinase (IKK) by modifying Cys179 of the IKKß subunit. Efficient inducer of mitochondrial membrane permeability transition via the inhibition of mitochondrial thioredoxin reductase (TrxR).
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 34031-32-8
Molecular Formula: C₂₀H₃₄AuO₉PS
Molecular Weight: 678.48
Purity: ≥98% by NMR
Solubility:DMSO (100 mM) or Ethanol (50 mM)
Storage Temp.: RT
Shipping Conditions: RT
Handling: Protect from light and moisture
SMILES: CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+]
InChi: InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1
InChi Key: AUJRCFUBUPVWSZ-UHFFFAOYSA-M
PubChem CID: 24199313
MDL Number: MFCD00080759
USAGE: For Research Use Only! Not For Use in Humans. |