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PX 12
An irreversible inhibitor of thioredoxin-1 (TRX-1)
Product Overview
Product Name: PX 12
Alternate Name/Synonyms: 2-[(1-Methylpropyl)dithio]-1H-imidazole; IV-2
Description: PX-12 is an irreversible inhibitor of thioredoxin-1 (TRX-1) (Ki = 31 µM). It decreases the expression of HIF-1α, VEGF and iNOS (IC₅₀ values are 7.2, ~10 and 18.1 μM respectively). Also known to display antitumor activity and inhibits tubulin polymerization in vitro.
Peptide Sequence: N/A
Appearance: Beige solid
Formulation: N/A
CAS Number: 141400-58-0
Molecular Formula: C₇H₁₂N₂S₂
Molecular Weight: 188.31
Purity: ≥98% by HPLC
Solubility:DMSO (100 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from light and moisture
SMILES: CCC(C)SSC1=NC=CN1
InChi: InChI=1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
InChi Key: BPBPYQWMFCTCNG-UHFFFAOYSA-N
PubChem CID: 219104
MDL Number: MFCD18086851
USAGE: For Research Use Only! Not For Use in Humans. |