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Thiocolchicine
A tubulin polymerization and microtubule assembly inhibitor
Product Overview
Product Name: Thiocolchicine
Alternate Name/Synonyms: 10-Demethoxy-10-methylthiocolchicine; NSC 186301
Description: An antimitotic alkaloid. Tubulin polymerization and microtubule assembly inhibitor and axonal cytoskeleton modulator; apoptosis inducer. Thiocolchicine-dimers were shown to be potent topoisomerase I inhibitors.
Peptide Sequence: N/A
Appearance: Yellow solid
Formulation: N/A
CAS Number: 2730-71-4
Molecular Formula: C₂₂H₂₅NO₅S
Molecular Weight: 415.5
Purity: ³95% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)SC)OC)OC)OC
InChi: InChI=1S/C22H25NO5S/c1-12(24)23-16-8-6-13-10-18(26-2)21(27-3)22(28-4)20(13)14-7-9-19(29-5)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)
InChi Key: CMEGANPVAXDBPL-UHFFFAOYSA-N
PubChem CID: 546854
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans. |