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MDL 28170
A potent calpain and cathepsin B inhibitor
Product Overview
Product Name: MDL 28170
Alternate Name/Synonyms: Z-Val-Phe-CHO; Carbobenzoxy-valinyl-phenylalaninal; Calpain Inhibitor III
Description: A potent, cell-permeable, and selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively). MDL 28170 does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Modulates the formation of Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation.
Peptide Sequence: Z-Val-Phe-CHO
Appearance: White solid
Formulation: N/A
CAS Number: 88191-84-8
Molecular Formula: C₂₂H₂₆N₂O₄
Molecular Weight: 382.45
Purity: ≥95% by HPLC
Solubility:DMSO (200 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC(C)C(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2
InChi: InChI=1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)
InChi Key: NGBKFLTYGSREKK-UHFFFAOYSA-N
PubChem CID: 9907994
MDL Number: MFCD00798796
USAGE: For Research Use Only! Not For Use in Humans. |