EIF2AK3 Activator, CCT020312 A dihydropyrazol derivative that acts as a selective activator of eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3/PERK) and increases the phosphorylation of EIF2A at Ser51 in HT29 and MCF7 cells. Does not inhibit the activity of cyclin dependent kinases, but causes a rapid loss of cyclin D expression. Also shown to block Rb protein phosphorylation (EC50 = 4.2 µM) in HT29 cells. Reported to sensitize cancer cells with defective taxane-induced EIF2A phosphorylation to paclitaxel treatment. Induces a long-term inhibition of cell proliferation even after its removal (GI50 = 3.1 µM). 产品信息 Form Yellowish-white solid Molar mass 650.4 Protect from Light 是的 Packaged under inert gas 是的 Purity ≥98% by HPLC Solubility DMSO Chemical formula C31H30Br2N4O2 商店和运输信息 Storage -20°C Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice Standard Handling
