Nrf2 Activator II, AI-1 Ethyl-4-chloro-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxylate A cell-permeable chloro-quinolinone compound that selectively and covalently modifies Kelch-like ECH-associated protein 1 (Keap1)-Cys151 and represses Keap1 function and reduces Nrf2 (Nuclear factor erythroid 2-related factor 2)-Keap1 interaction. Shown to stabilize Nrf2 by inhibiting the Keap1-driven ubiquitination of Nrf2 and thereby activating the Nrf2-ARE (antioxidant response element) pathway (EC50 = 2.7 µM in neuroblastoma IMR-32 cells). Offers protection against H2O2 induced oxidative stress, but unlike tert-butylhydroquinone (Cat. No. 286888). AI-1 does not act as a free radical scavenger. Its anti-oxidant effects are mediated via Nrf2 induced antioxidant response. Does not affect mutant ARE where GC are substituted with AT within the core ARE sequence. 产品信息 Form Off-white solid Primary Target Keap1 Molar mass 265.7 Protect from Light 是的 Protect from Moisture 是的 Packaged under inert gas 是的 Cell permeable 是的 Purity ≥97% by HPLC Solubility DMSO CAS number 75483-04-4 商店和运输信息 Storage +2°C to +8°C Ship Ambient Temperature Only Standard Handling